Another way to setting up the atom positions is to use Cartesian coordinates. In this type of coordinate, the atoms have absolute positions, i.e., don't depend on cell parameters.
In many DFT codes, you can use both type of coordinates to represent your system in the input files.
My question: is there any performance difference in using one type over the other one?
PS: in general, I work with systems where I have to add a vacuum region that, a priori, I don't know how big will be, so, I use Cartesian coordinates.