What are some of the biggest open-questions / challenges in Condensed Phase theory and computation? What efforts are being done to answer them?
I realize Condensed Phase chemistry is a huge field, but there must be those questions that "everyone knows" are still open (e.g. Room-Temperature Superconductivity in Condensed Matter Physics, functional Spintronic devices).
I am thinking there are some challenges in really predicting reactions in complex environments... any references a beginner should look at?