Motivated by the ongoing COVID-19 pandemic, I am wondering how established density functional theory (DFT) is as a tool/technique in drug design.
Drug molecules come in a wide range of sizes from small molecules (e.g. aspirin) to proteins (biologics) that have complicated intramolecular and intermolecular interactions in a physiological environment, which is often highly concentrated. Is DFT a commonly used tool/technique in drug design? Or is DFT too expensive and inaccurate for us to perform first-principles prediction of drug properties?