In regression models to predict chemical compounds' activities, fingerprints are often used as features. Should one normalize a fingerprint feature to be in the 0-1 range?

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    $\begingroup$ I've posted this question in a chat room with some machine learning experts, and there's a question about whether you're doing ordinary least-squares regression or maximum likelihood estimation procedures. Perhaps you can join that discussion and we can converge closer to an answer for you: chat.stackexchange.com/transcript/message/56950547#56950547 $\endgroup$ – Nike Dattani Feb 3 at 16:21

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